A prison ship on its way to a remote island prison runs aground on rocks and sinks. Mixed survivors of cons and prison guards struggle ashore, only to discover to their horror that another survivor has made it ashore before them. Murderous psychotic, Leo Rook, who not only had a hand in the ship's sinking but has decapitated all but one of the island's lighthouse crew. Stranded, with no means of escape or call for help, the survivors must face a night of terror as they know that since they've learned that Leo survived going down with the ship he can't let any of them live and is hellbent on adding their severed heads to his collection.

At the end of the Ice Age, The Machine came from outer space with the purpose to change men into mutants. However, a hero defeated the device and a great seal was laid over The Machine. In 2707, the depleted world is ruled by four Corporations: Mishima, Bauhaus, Capitol and Imperial that are in a constant state of war. During a battle between Capitol and Bauhaus, the great seal is broken and The Machine works again transforming soldiers and civilians into hordes of mutants. A small part of the population escapes to Mars, leaving millions of people behind. The man of faith and leader of an ancient brotherhood, Brother Samuel, is a believer in God and the Chronicles, a bible about the mutants from ancient times. With the city besieged by the mutants, he visits the Corporations' leader Constantine, asking for an aircraft and twenty men for a suicide mission to destroy The Machine, planting a bomb and a detonator following the knowledge of the Chronicles...